Pu·MA System

 Automated 3D Cell-Based Assays


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Ready to automate your 3D cell-based assay?

At Protein Fluidics we enable automated assays for 3D cell models, organoids or spheroids to achieve multifunctional profiling. We support applications such as oncology, neuroscience, drug discovery and metabolic disease research. By combining microfluidics, our proprietary design and 3D assay technology, we can help streamline your workflows.

Pu·MA System

The combination of Pu·MA System and 3D Flowchips enables the automated workflows. This system maintains the organoids in a unique sample chamber and allows easy media, metabolite or reagent exchanges for oncology, toxicity, or metabolomics research.  This system can help you get multiple data points from one single assay workflow.


3D Assay Technology

Our proprietary microfluidic technology allows for precise control of fluid movement within the flowchips. The various protocol steps are executed via the touchscreen on the Pu·MA System.

Assay workflows enabled by our technology:

  • In situ supernatant sampling
  • Sequential drug addition
  • In situ lysis for metabolomics
  • Immunofluorescence workflow

Multifunctional Profiling from the Pu·MA System Workflow

multifunctional profiling from organoids

Featured Application

Transfer, Automated Staining, and Imaging of Organoids in Matrigel using the Pu·MA System
View our webinar recording featuring this application
HeLa Spheroids stained for apoptotic and mitochondrial markers and imaged at 10X and 20X


Disease Modeling with 3D Cell-Based Assays Using a Novel Flowchip System and High-Content Imaging.

Cromwell EF et al., SLAS TECHNOLOGY Mar 30, 2021 26(3):237-248

Automated organoid assay workflow for imaging and in situ sampling
HepG2 spheroids treated with increasing Staurosporine; staining and in situ sampling


Check out the multifunctional profiling data from different 3D cell models in our various technical resources


Join the Protein Fluidics team at one of these upcoming events!


Jul 13

Pu·MA System Assays for
Matrigel-Grown Organoids

Contact Us

Protein Fluidics, Inc.

875 Cowan Road, Suite B,
Burlingame, CA 94010

+1 650 529 5080


Our Company

For Research Use Only. Not for diagnostic use. Protein Fluidics, Protein Fluidics Logo and Pu•MA System are registered trademarks of Protein Fluidics, Inc. in the United States and internationally. All rights reserved. © 2021 PROTEIN FLUIDICS, INC.